Emotional dysregulation is common following traumatic brain injury (TBI). Irritability and aggression are both estimated to be present in approximately 29-73% of individuals with TBI, contributing to social isolation, care burden, disrupted interpersonal relationships and difficulties in community integration. The published literature in this area is sparse making it difficult for researchers and clinicians to make sense of the pathophysiology, possible effective treatments, and emerging strategies. The prevalence and impact of emotion regulation difficulties on the lives of individuals with TBI and their families will be discussed briefly. The literature regarding the neurobiology of emotional regulation, as well as the pharmacologic and non-pharmacologic treatments addressing this problem will be reviewed critically. The review includes studies completed by the speakers in this area. The talks will focus on the clinical implications of available knowledge and translation into practice.